before
What to expect before
each infusion
- DANYELZA is used with another medicine called granulocyte-macrophage colony-stimulating factor (GM-CSF). GM-CSF can be given at home and starts 5 days before the first DANYELZA infusion
- Preventive pain medicine (eg, gabapentin) may also be given at home starting 5 days before the first DANYELZA infusion
Be sure to ask your doctor if these medicines can be picked up at your local pharmacy
during
What to expect at the treatment center on infusion days
- On Day 1 of Cycle 1, the DANYELZA infusion will be 60 minutes. The rest of the DANYELZA infusions will be 30-60 minutes, as tolerated
- Your child will be monitored for at least 2 hours following each DANYELZA infusion
- Your child will receive additional medicines before and during DANYELZA infusions to help manage side effects such as pain, infusion-related reactions, and nausea/vomiting. Ask your doctor about these additional medicines
See more details about managing side effects in the section below
after
What to expect after
each infusion
Make sure you monitor your child’s blood pressure through 8 days after Day 1 of each treatment cycle
- Since every child is different, it’s difficult to know exactly how many treatment cycles your child may need
- Once your child’s doctor sees an initial response to treatment, DANYELZA will be given for another 5 cycles every 4 weeks. From there, your doctor may repeat treatment cycles every 8 weeks
- Your child’s doctor will continue monitoring your child’s response to determine if treatment should continue. They will stop treatment if your child’s disease progresses or if they cannot tolerate the side effects

“The ability to perform this treatment outpatient really helped our family.”
–Spencer, actual DANYELZA caregiver
Managing side effects before and during DANYELZA treatment
Because some side effects are to be expected during DANYELZA treatment, there are recommendations that your child’s care team will follow to help manage them. Your child’s care team will give your child certain medicines before and during DANYELZA infusions to help manage pain and infusion-related reactions.
For more details about safety, see the serious side effects >
Managing pain
Pain is common with DANYELZA and can be severe. Your child will likely experience pain during the infusion. In the clinical studies, pain usually lasted less than a day, but in some cases, it lasted longer. Your child’s care team may give your child the following medicines based on their condition:
- Preventive pain medicine (eg, gabapentin). Given for 12 days starting 5 days before the first DANYELZA infusion in each cycle
- Other pain medicine (eg, opioids). Given approximately an hour before infusion and may be administered by IV as needed for additional pain during the infusion
- Anesthetic (eg, ketamine). Given if the pain is not adequately controlled by opioids. This may make your child sleepy during the infusion